Assay Detail
Binding
CHEMBL1286071
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Inhibition of Candida albicans zinc dependent class 2 Fba
13
Total Activities
7
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Fructose-bisphosphate aldolase (CHEMBL1287619) ↗| Type | SINGLE PROTEIN |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Publication
Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.59 | 8.52 |
| Km | 1 | - | - |
| IC50 | 1 | 8.32 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236228 | — | — | 4 | 8.52 |
| CHEMBL1235276 | — | — | 1 | 6.70 |
| CHEMBL1278086 | — | — | 2 | 6.56 |
| CHEMBL1236227 | — | — | 2 | 6.53 |
| CHEMBL1276292 | — | — | 1 | 6.40 |
| CHEMBL1278173 | — | — | 2 | 6.10 |
| CHEMBL1235112 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236228 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1236228 | — | Ki | = | 3.25 | nM | 8.49 |
| CHEMBL1236228 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1235276 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL1278086 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL1278086 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL1236227 | — | Ki | = | 297.0 | nM | 6.53 |
| CHEMBL1236227 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL1276292 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL1278173 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL1278173 | — | Ki | = | 815.0 | nM | 6.09 |
| CHEMBL1235112 | — | Ki | = | 85000.0 | nM | 4.07 |
| CHEMBL1236228 | — | Km | = | 100000.0 | nM | - |