Assay Detail
Binding
CHEMBL1286208
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Antiprion activity against scrapie prion protein-infected mouse ScGT1 cells assessed as accumulation of PrPSc after 5 days by Western blotting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | ScGT1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Parallel synthesis, evaluation, and preliminary structure-activity relationship of 2,5-diamino-1,4-benzoquinones as a novel class of bivalent anti-prion compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.30 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1275680 | — | — | 1 | 6.77 |
| CHEMBL92547 | — | — | 1 | 6.50 |
| CHEMBL1275674 | — | — | 1 | 6.17 |
| CHEMBL1277344 | — | — | 1 | 6.14 |
| CHEMBL1275676 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1275680 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL92547 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1275674 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1277344 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1275676 | — | EC50 | = | 1200.0 | nM | 5.92 |