Assay Detail
ADMET
CHEMBL1286355
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Cytotoxicity against human BJ cells after 48 hrs by Alamar blue assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | BJ |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sterols as anticancer agents: synthesis of ring-B oxygenated steroids, cytotoxic profile, and comprehensive SAR analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.85 | 5.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.63 |
| CHEMBL1277284 | — | — | 1 | 4.80 |
| CHEMBL1278089 | CHOLESTAN-3beta,5alpha,6beta-TRIOL | — | 1 | 4.73 |
| CHEMBL497834 | — | — | 1 | 4.70 |
| CHEMBL455367 | — | — | 1 | 4.66 |
| CHEMBL1277103 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL1277284 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL1278089 | CHOLESTAN-3beta,5alpha,6beta-TRIOL | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL497834 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL455367 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL1277103 | — | IC50 | = | 26200.0 | nM | 4.58 |