Assay Detail
Binding
CHEMBL1286470
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.38 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1277241 | — | — | 1 | 7.70 |
| CHEMBL1276973 | DE-O-SULFONATED KOTALANOL | — | 1 | 7.52 |
| CHEMBL1277240 | — | — | 1 | 7.22 |
| CHEMBL1277153 | — | — | 1 | 7.10 |
| CHEMBL1093264 | KOTALANOL | — | 1 | 6.72 |
| CHEMBL1561 | MIGLITOL | 4.0 | 1 | 6.00 |
| CHEMBL1208974 | SALACINOL | — | 1 | 6.00 |
| CHEMBL1277063 | — | — | 1 | 5.85 |
| CHEMBL1277062 | — | — | 1 | 5.64 |
| CHEMBL1277152 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1277241 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1276973 | DE-O-SULFONATED KOTALANOL | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1277240 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL1277153 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL1093264 | KOTALANOL | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL1561 | MIGLITOL | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1208974 | SALACINOL | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1277063 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL1277062 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL1277152 | — | Ki | = | 90000.0 | nM | 4.05 |