Assay Detail
Binding
CHEMBL1286654
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Fischer-344 rat lens ALR2 by least-square analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Lens of camera-type eye |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.71 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1277476 | — | — | 1 | 6.40 |
| CHEMBL1277386 | — | — | 1 | 5.24 |
| CHEMBL1277203 | — | — | 1 | 5.10 |
| CHEMBL1277387 | — | — | 1 | 5.05 |
| CHEMBL1277297 | — | — | 1 | 4.92 |
| CHEMBL507525 | — | — | 1 | 4.85 |
| CHEMBL458588 | — | — | 1 | 4.81 |
| CHEMBL1277477 | — | — | 1 | 4.55 |
| CHEMBL458568 | — | — | 1 | 4.48 |
| CHEMBL1277298 | — | — | 1 | 4.42 |
| CHEMBL457486 | — | — | 1 | 4.35 |
| CHEMBL1277202 | — | — | 1 | 4.24 |
| CHEMBL1275967 | — | — | 1 | 4.15 |
| CHEMBL37054 | — | — | 1 | 4.06 |
| CHEMBL1277113 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1277476 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL1277386 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1277203 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL1277387 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1277297 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL507525 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL458588 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL1277477 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL458568 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL1277298 | — | IC50 | = | 37800.0 | nM | 4.42 |
| CHEMBL457486 | — | IC50 | = | 44400.0 | nM | 4.35 |
| CHEMBL1277202 | — | IC50 | = | 57100.0 | nM | 4.24 |
| CHEMBL1275967 | — | IC50 | = | 71200.0 | nM | 4.15 |
| CHEMBL37054 | — | IC50 | = | 86700.0 | nM | 4.06 |
| CHEMBL1277113 | — | IC50 | = | 91500.0 | nM | 4.04 |