Assay Detail
Functional
CHEMBL1286820
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Cytotoxicity against mouse L1210 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 9.19 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | — | 1 | 11.00 |
| CHEMBL139109 | (+)-CC-1065 | — | 1 | 10.70 |
| CHEMBL1276856 | SECO-CBI-INDOLE | — | 1 | 10.52 |
| CHEMBL1276142 | — | — | 1 | 10.10 |
| CHEMBL1276143 | — | — | 1 | 10.00 |
| CHEMBL1276144 | — | — | 1 | 9.30 |
| CHEMBL1276943 | — | — | 1 | 9.05 |
| CHEMBL1276145 | — | — | 1 | 9.05 |
| CHEMBL1276146 | — | — | 1 | 8.96 |
| CHEMBL1276147 | — | — | 1 | 8.46 |
| CHEMBL1276148 | — | — | 1 | 8.40 |
| CHEMBL1276149 | — | — | 1 | 8.05 |
| CHEMBL1276151 | — | — | 1 | 7.52 |
| CHEMBL1276150 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL139109 | (+)-CC-1065 | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL1276856 | SECO-CBI-INDOLE | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL1276142 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL1276143 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL1276144 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1276943 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1276145 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1276146 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1276147 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL1276148 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1276149 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1276151 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1276150 | — | IC50 | = | 30.0 | nM | 7.52 |