Compound Detail
CHEMBL139109
(+)-CC-1065 Enter ChEMBL ID:
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COc1c(O)c2c(c3cc(C(=O)N4CCc5c4c(O)c(OC)c4[nH]c(C(=O)N6C[C@H]7C[C@@]78C6=CC(=O)c6[nH]cc(C)c68)cc54)[nH]c13)CCN2C(N)=O
Basic Information
| ChEMBL ID | CHEMBL139109 |
| Name | (+)-CC-1065 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UOWVMDUEMSNCAV-WYENRQIDSA-N |
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
17
Publications
0
Known Names
Molecular Properties
703.7
MW (Da)
3.85
ALogP
8
HBA
6
HBD
210.3
PSA (Ų)
0.16
QED
2
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 10.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| L1210 CHEMBL386 | IC50 | 10.7 | 9.7933 | 0.0 | 6 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| L1210 | IC50 | = | 0.02 | nM | 10.7 | Cytotoxicity against mouse L1210 cells | 20942408 |
| L1210 | IC50 | = | 0.02 | nM | 10.7 | Cytotoxicity against mouse L1210 cells | 22650244 |
| L1210 | IC50 | = | 0.02 | nM | 10.7 | Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 72 hr... | 23627265 |
| L1210 | IC50 | = | 0.024 | nM | 10.62 | Cytotoxicity against mouse L1210 cells after 3 days by coulter counter analysis | 25963825 |
| L1210 | IC50 | = | 0.03 | nM | 10.52 | Cytotoxicity against mouse L1210 cells after 3 days by MTT assay | 20579889 |
| L1210 | IC50 | = | 3000.0 | nM | 5.52 | Concentration of the drug to inhibit L1210 leukemia cell growth in culture | 7527862 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)81090-8 | Unchecked | 2 |
| - | 10.1016/S0960-894X(01)81090-8 | L1210 | 2 |
| 3346875 | 10.1021/jm00398a017 | P388 | 2 |
| 8336335 | 10.1021/jm00066a004 | Mus musculus | 2 |
| 25963825 | 10.1016/j.bmc.2015.04.034 | Calf thymus DNA | 1 |
| 25963825 | 10.1016/j.bmc.2015.04.034 | L1210 | 1 |
| 23627265 | 10.1021/jm400413r | L1210 | 1 |
| 22650244 | 10.1021/jm300330b | L1210 | 1 |
| 20942408 | 10.1021/jm1010397 | L1210 | 1 |
| 20579889 | 10.1016/j.bmc.2010.05.078 | L1210 | 1 |
| 1479377 | 10.1021/np50089a004 | Calf thymus DNA | 1 |
| 1479377 | 10.1021/np50089a004 | Nucleic Acid | 1 |
| 16919946 | 10.1016/j.bmcl.2006.08.005 | Unchecked | 1 |
| 7527862 | 10.1021/jm00051a010 | L1210 | 1 |
| 3346875 | 10.1021/jm00398a017 | L1210 | 1 |
| 3346875 | 10.1021/jm00398a017 | Nucleic Acid | 1 |
| 3346875 | 10.1021/jm00398a017 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine