Assay Detail
Functional
CHEMBL2157112
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Cytotoxicity against mouse L1210 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.74 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | — | 1 | 11.00 |
| CHEMBL139109 | (+)-CC-1065 | — | 1 | 10.70 |
| CHEMBL2152765 | — | — | 1 | 10.70 |
| CHEMBL1276856 | SECO-CBI-INDOLE | — | 1 | 10.52 |
| CHEMBL146774 | — | — | 1 | 10.00 |
| CHEMBL2152762 | — | — | 1 | 9.68 |
| CHEMBL1276943 | — | — | 1 | 9.05 |
| CHEMBL2152764 | — | — | 1 | 8.18 |
| CHEMBL2152767 | — | — | 1 | 7.40 |
| CHEMBL80596 | — | — | 1 | 7.10 |
| CHEMBL2152763 | — | — | 1 | 5.31 |
| CHEMBL2152766 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL139109 | (+)-CC-1065 | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL2152765 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL1276856 | SECO-CBI-INDOLE | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL146774 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL2152762 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL1276943 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2152764 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL2152767 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL80596 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2152763 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL2152766 | — | IC50 | = | 5800.0 | nM | 5.24 |