Assay Detail

CHEMBL3588710

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Functional

Cytotoxicity against mouse L1210 cells after 3 days by coulter counter analysis

ChEMBL ↗

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Target

L1210 (CHEMBL386) ↗

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Primary target L1210

CHEMBL386

Anchored from Assay target.

Protein identity L1210

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	L1210
Confidence	1 — Organism
Curated By	Autocuration

Target

L1210 (CHEMBL386) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems.

Twum EA, Nathubhai A, Wood PJ, Lloyd MD, Thompson AS, Threadgill MD.
Bioorg Med Chem (2015) 23 : 3481 -3489
PubMed 25963825 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	10.62	10.62

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL139109	(+)-CC-1065	—	1	10.62

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL139109	(+)-CC-1065	IC50	=	0.024	nM	10.62