Assay Detail
Binding
CHEMBL1287585
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Displacement of [3H]CP-55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-Bromo-3-(1',1'-dimethylalkyl)-1-deoxy-Δ(8)-tetrahydrocannabinols: New selective ligands for the cannabinoid CB(2) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.33 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371214 | — | — | 1 | 8.47 |
| CHEMBL498346 | — | — | 1 | 7.75 |
| CHEMBL1277592 | — | — | 1 | 7.55 |
| CHEMBL1277593 | — | — | 1 | 7.47 |
| CHEMBL465 | DRONABINOL | 4.0 | 1 | 7.44 |
| CHEMBL1277499 | — | — | 1 | 7.15 |
| CHEMBL1277498 | — | — | 1 | 6.58 |
| CHEMBL1277409 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371214 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL498346 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL1277592 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL1277593 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL465 | DRONABINOL | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL1277499 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL1277498 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL1277409 | — | Ki | = | 555.0 | nM | 6.26 |