Assay Detail
Functional
CHEMBL1287587
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Agonist activity at human CB2 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 1.5 hrs by liquid scintillation spectrophotometry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-Bromo-3-(1',1'-dimethylalkyl)-1-deoxy-Δ(8)-tetrahydrocannabinols: New selective ligands for the cannabinoid CB(2) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.03 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371214 | — | — | 1 | 8.40 |
| CHEMBL498346 | — | — | 1 | 8.34 |
| CHEMBL1277593 | — | — | 1 | 7.82 |
| CHEMBL1277592 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371214 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL498346 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1277593 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1277592 | — | EC50 | = | 28.6 | nM | 7.54 |