Assay Detail
Binding
CHEMBL1290837
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length human CA1 cytosolic isoform by stopped-flow CO2 hydration method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 5.62 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL572366 | — | — | 1 | 7.11 |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | 5.51 |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | 4.23 |
| CHEMBL1288534 | — | — | 1 | - |
| CHEMBL1288535 | — | — | 1 | - |
| CHEMBL446518 | — | — | 1 | - |
| CHEMBL1288557 | — | — | 1 | - |
| CHEMBL1288558 | — | — | 1 | - |
| CHEMBL1288559 | — | — | 1 | - |
| CHEMBL1288560 | — | — | 1 | - |
| CHEMBL1288593 | — | — | 1 | - |
| CHEMBL1290010 | — | — | 1 | - |
| CHEMBL1290110 | — | — | 1 | - |
| CHEMBL1288594 | — | — | 1 | - |
| CHEMBL1288595 | — | — | 1 | - |
| CHEMBL1288596 | — | — | 1 | - |
| CHEMBL1288620 | — | — | 1 | - |
| CHEMBL1290111 | — | — | 1 | - |
| CHEMBL1290219 | — | — | 1 | - |
| CHEMBL1288621 | — | — | 1 | - |
| CHEMBL1288622 | — | — | 1 | - |
| CHEMBL1288623 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL572366 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL6466 | COUMARIN | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL51628 | UMBELLIFERONE | Ki | = | 58400.0 | nM | 4.23 |
| CHEMBL1288534 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1288535 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL446518 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1288557 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1288558 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1288559 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1288560 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1288593 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1290010 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1290110 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1288594 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1288595 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1288596 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1288620 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1290111 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1290219 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1288621 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1288622 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1288623 | — | Ki | > | 100000.0 | nM | - |