Assay Detail
Functional
CHEMBL1291269
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Cytotoxicity against human U251 after 48 hrs by SRB assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-251 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-κB activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.48 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404613 | DEOXYBOUVARDIN | — | 1 | 9.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.52 |
| CHEMBL1288982 | RUBIYUNNANIN C | — | 1 | 6.12 |
| CHEMBL1288988 | — | — | 1 | 5.71 |
| CHEMBL1288991 | — | — | 1 | 5.09 |
| CHEMBL1288990 | — | — | 1 | 5.00 |
| CHEMBL1288989 | — | — | 1 | 4.97 |
| CHEMBL1288985 | RUBIYUNNANIN F | — | 1 | 4.82 |
| CHEMBL1288983 | RUBIYUNNANIN D | — | 1 | 4.58 |
| CHEMBL1288987 | RUBIYUNNANIN H | — | 1 | 4.37 |
| CHEMBL1288986 | RUBIYUNNANIN G | — | 1 | 4.31 |
| CHEMBL1288984 | RUBIYUNNANIN E | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404613 | DEOXYBOUVARDIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1288982 | RUBIYUNNANIN C | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1288988 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL1288991 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1288990 | — | IC50 | = | 10030.0 | nM | 5.00 |
| CHEMBL1288989 | — | IC50 | = | 10810.0 | nM | 4.97 |
| CHEMBL1288985 | RUBIYUNNANIN F | IC50 | = | 14990.0 | nM | 4.82 |
| CHEMBL1288983 | RUBIYUNNANIN D | IC50 | = | 26250.0 | nM | 4.58 |
| CHEMBL1288987 | RUBIYUNNANIN H | IC50 | = | 42310.0 | nM | 4.37 |
| CHEMBL1288986 | RUBIYUNNANIN G | IC50 | = | 48610.0 | nM | 4.31 |
| CHEMBL1288984 | RUBIYUNNANIN E | IC50 | = | 56240.0 | nM | 4.25 |