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Compound Detail

CHEMBL1288987

RUBIYUNNANIN H
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COc1ccc(C[C@H]2C(=O)N[C@@H](C)C(=O)N(C)[C@H]3Cc4ccc(cc4)Oc4cc(ccc4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@H](O)[C@@H](C(=O)N[C@H](C)C(=O)N[C@@H](C)C(=O)N2C)N(C)C3=O)cc1

Basic Information

ChEMBL ID CHEMBL1288987
Name RUBIYUNNANIN H
Phase Preclinical
Structure Type MOL
InChI Key ZDSCVBHZIXKZSG-DMUSRQITSA-N
7
Targets
8
Activities
1
Assay Types
0
PK Parameters
13
Publications
0
Known Names

Molecular Properties

935.0
MW (Da)
-1.49
ALogP
15
HBA
8
HBD
286.3
PSA (Ų)
0.14
QED
3
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C46H58N6O15
MW 935.00
Aromatic Rings 3
Heavy Atoms 67
NP-Likeness 1.51

Activity Summary

IC50 8 meas. best 4.9

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
RAW264.7
CHEMBL612557
IC50 4.9 4.9 12680.0 2
B16
CHEMBL381
IC50 4.53 4.53 29240.0 1
A549
CHEMBL392
IC50 4.48 4.48 32820.0 1
SMMC-7721
CHEMBL613831
IC50 4.44 4.44 35970.0 1
HepG2
CHEMBL395
IC50 4.38 4.38 41350.0 1
U-251
CHEMBL615022
IC50 4.37 4.37 42310.0 1
HeLa
CHEMBL399
IC50 4.32 4.32 48170.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine