Assay Detail
Binding
CHEMBL1292995
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human IMPDH1 expressed in Escherichia coli strain BL21(DE3) after 60 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inosine-5'-monophosphate dehydrogenase 1 (CHEMBL1822) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycophenolic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.07 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 7.72 |
| CHEMBL132727 | — | — | 1 | 6.82 |
| CHEMBL238461 | MYCOPHENOLIC HYDROXAMIC ACID | — | 1 | 6.46 |
| CHEMBL157617 | — | — | 1 | 6.11 |
| CHEMBL237760 | — | — | 1 | 5.82 |
| CHEMBL238403 | — | — | 1 | 5.39 |
| CHEMBL437376 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL132727 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL238461 | MYCOPHENOLIC HYDROXAMIC ACID | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL157617 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL237760 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL238403 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL437376 | — | IC50 | = | 67000.0 | nM | 4.17 |