Assay Detail
Functional
CHEMBL1613790
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: SAR analysis of compounds that potentiate TRAIL-induced apoptosis in MDA-MB-435 cells. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1443, AID1447, AID1624, AID1640]
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tumor necrosis factor ligand superfamily member 10 (CHEMBL5813) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.63 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1570732 | — | — | 1 | 6.09 |
| CHEMBL1411210 | — | — | 2 | 5.49 |
| CHEMBL1455032 | — | — | 1 | - |
| CHEMBL1527479 | — | — | 1 | - |
| CHEMBL1370388 | — | — | 1 | - |
| CHEMBL1568314 | — | — | 1 | - |
| CHEMBL1407233 | — | — | 1 | - |
| CHEMBL1449091 | — | — | 1 | - |
| CHEMBL1324345 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1570732 | — | IC50 | = | 806.0 | nM | 6.09 |
| CHEMBL1411210 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL1411210 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL1455032 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1527479 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1370388 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1568314 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1407233 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1449091 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1324345 | — | IC50 | > | 10000.0 | nM | - |