Assay Detail
Functional
CHEMBL1613837
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify activators of signal transducer and activator of transcription 1 (STAT1): luminescence-based cell-based dose response assay for STAT1 activators. (Class of assay: confirmatory) [Related pubchem assays: 1404 (Dose response counterscreen (STAT3 activators in triplicate)), 1262 (Confirmation screen (STAT1 activators in triplicate)), 1804 (Summary (STAT1 activators)), 1397 (Dose response (STAT1 activators in triplicate)), 932 (Primary screen (STAT1 activators in singlicate)), 1316 (Counterscreen (STAT3 activators in triplicate)), 1306 (Counterscreen (NF-kappaB activators in triplicate))]
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 1-alpha/beta (CHEMBL6101) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.81 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1398377 | — | — | 1 | 7.19 |
| CHEMBL1316867 | — | — | 1 | 6.08 |
| CHEMBL1333621 | — | — | 1 | 5.70 |
| CHEMBL1332452 | — | — | 1 | 5.48 |
| CHEMBL1393635 | — | — | 1 | 5.39 |
| CHEMBL1497574 | — | — | 1 | 5.00 |
| CHEMBL1328302 | — | — | 1 | - |
| CHEMBL1369691 | — | — | 1 | - |
| CHEMBL85826 | — | — | 1 | - |
| CHEMBL1449208 | — | — | 1 | - |
| CHEMBL1409658 | — | — | 1 | - |
| CHEMBL1371289 | — | — | 1 | - |
| CHEMBL1554201 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1398377 | — | EC50 | = | 64.3 | nM | 7.19 |
| CHEMBL1316867 | — | EC50 | = | 834.72 | nM | 6.08 |
| CHEMBL1333621 | — | EC50 | = | 2011.0 | nM | 5.70 |
| CHEMBL1332452 | — | EC50 | = | 3307.0 | nM | 5.48 |
| CHEMBL1393635 | — | EC50 | = | 4037.0 | nM | 5.39 |
| CHEMBL1497574 | — | EC50 | = | 10006.0 | nM | 5.00 |
| CHEMBL1328302 | — | EC50 | > | 55690.0 | nM | - |
| CHEMBL1369691 | — | EC50 | > | 687.51 | nM | - |
| CHEMBL85826 | — | EC50 | < | 2.83 | nM | - |
| CHEMBL1449208 | — | EC50 | > | 55690.0 | nM | - |
| CHEMBL1409658 | — | EC50 | > | 76.39 | nM | - |
| CHEMBL1371289 | — | EC50 | > | 55690.0 | nM | - |
| CHEMBL1554201 | — | EC50 | > | 229.17 | nM | - |