Assay Detail
Functional
CHEMBL1614159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Mode of action assay - current amplitude concentration response for derivatives of ZTZ240, a potentiator of KCNQ2 potassium channels. (Class of assay: confirmatory) [Related pubchem assays: 2258 (Summary assay for the KCNQ2 potentiators.), 2239 (Primary HTS assay for KCNQ2 potentiators with 305606 compounds tested, and 1644 are found to be active.)]
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily KQT member 2 (CHEMBL5530) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.47 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1454208 | — | — | 1 | 5.84 |
| CHEMBL1356888 | — | — | 1 | 5.78 |
| CHEMBL1592508 | — | — | 1 | 5.43 |
| CHEMBL402146 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1454208 | — | EC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL1356888 | — | EC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL1592508 | — | EC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL402146 | — | EC50 | = | 14400.0 | nM | 4.84 |