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Assay Detail

CHEMBL1614199

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
PUBCHEM_BIOASSAY: Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 629 (Primary screen preceding this dose response confirmation assay.)]
ChEMBL ↗
439
Total Activities
439
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Category confirmatory
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Estrogen receptor (CHEMBL206) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 439 4.78 5.67

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL496 HEXACHLOROPHENE 4.0 1 5.67
CHEMBL51483 GOSSYPOL 3.0 1 5.59
CHEMBL1452952 — — 1 5.56
CHEMBL1577661 — — 1 5.53
CHEMBL1506716 — — 1 5.52
CHEMBL1570364 — — 1 5.51
CHEMBL1427879 — — 1 5.51
CHEMBL1330161 — — 1 5.45
CHEMBL1331084 — — 1 5.44
CHEMBL1372307 — — 1 5.42
CHEMBL3212870 — — 1 5.41
CHEMBL290106 BITHIONOL 4.0 1 5.40
CHEMBL1581690 — — 1 5.39
CHEMBL1538223 — — 1 5.37
CHEMBL1421887 — — 1 5.33
CHEMBL1493034 — — 1 5.32
CHEMBL1326210 — — 1 5.30
CHEMBL1431555 — — 1 5.30
CHEMBL3190827 — — 1 5.29
CHEMBL1407483 — — 1 5.29
CHEMBL1442697 — — 1 5.28
CHEMBL1462307 — — 1 5.24
CHEMBL377295 — — 1 5.24
CHEMBL1507012 — — 1 5.20
CHEMBL1429150 — — 1 5.20
CHEMBL1577029 — — 1 5.18
CHEMBL1613068 — — 1 5.18
CHEMBL1413557 — — 1 5.17
CHEMBL1324290 — — 1 5.17
CHEMBL1972915 — — 1 5.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL496 HEXACHLOROPHENE IC50 = 2161.56 nM 5.67
CHEMBL51483 GOSSYPOL IC50 = 2551.34 nM 5.59
CHEMBL1452952 — IC50 = 2769.48 nM 5.56
CHEMBL1577661 — IC50 = 2947.59 nM 5.53
CHEMBL1506716 — IC50 = 3016.42 nM 5.52
CHEMBL1570364 — IC50 = 3106.81 nM 5.51
CHEMBL1427879 — IC50 = 3062.6 nM 5.51
CHEMBL1330161 — IC50 = 3548.86 nM 5.45
CHEMBL1331084 — IC50 = 3639.79 nM 5.44
CHEMBL1372307 — IC50 = 3818.74 nM 5.42
CHEMBL3212870 — IC50 = 3852.88 nM 5.41
CHEMBL290106 BITHIONOL IC50 = 3940.88 nM 5.40
CHEMBL1581690 — IC50 = 4112.5 nM 5.39
CHEMBL1538223 — IC50 = 4234.1 nM 5.37
CHEMBL1421887 — IC50 = 4691.78 nM 5.33
CHEMBL1493034 — IC50 = 4827.43 nM 5.32
CHEMBL1326210 — IC50 = 4982.94 nM 5.30
CHEMBL1431555 — IC50 = 5018.36 nM 5.30
CHEMBL3190827 — IC50 = 5150.58 nM 5.29
CHEMBL1407483 — IC50 = 5104.59 nM 5.29
CHEMBL1442697 — IC50 = 5194.54 nM 5.28
CHEMBL377295 — IC50 = 5729.13 nM 5.24
CHEMBL1462307 — IC50 = 5732.94 nM 5.24
CHEMBL1507012 — IC50 = 6299.84 nM 5.20
CHEMBL1429150 — IC50 = 6261.99 nM 5.20
CHEMBL1613068 — IC50 = 6621.2 nM 5.18
CHEMBL1577029 — IC50 = 6674.21 nM 5.18
CHEMBL1324290 — IC50 = 6840.09 nM 5.17
CHEMBL1413557 — IC50 = 6844.46 nM 5.17
CHEMBL1972915 — IC50 = 6835.45 nM 5.17
CHEMBL1520373 — IC50 = 6904.21 nM 5.16
CHEMBL1320937 — IC50 = 6975.21 nM 5.16
CHEMBL1403999 — IC50 = 7037.86 nM 5.15
CHEMBL1388431 — IC50 = 7107.47 nM 5.15
CHEMBL1417890 — IC50 = 7092.12 nM 5.15
CHEMBL3208556 — IC50 = 7316.61 nM 5.14
CHEMBL577758 — IC50 = 7189.32 nM 5.14
CHEMBL1300008 — IC50 = 7237.52 nM 5.14
CHEMBL1388271 — IC50 = 7467.87 nM 5.13
CHEMBL1386537 — IC50 = 7598.93 nM 5.12
CHEMBL1559731 — IC50 = 7534.84 nM 5.12
CHEMBL1343011 — IC50 = 7851.33 nM 5.11
CHEMBL1305485 — IC50 = 7983.25 nM 5.10
CHEMBL1448466 — IC50 = 7938.99 nM 5.10
CHEMBL3189964 — IC50 = 8195.18 nM 5.09
CHEMBL1443090 — IC50 = 8229.68 nM 5.08
CHEMBL1312859 — IC50 = 8308.43 nM 5.08
CHEMBL1431081 — IC50 = 8345.14 nM 5.08
CHEMBL1509453 — IC50 = 8438.21 nM 5.07
CHEMBL1526157 — IC50 = 8475.25 nM 5.07