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Assay Detail

CHEMBL1614460

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Category confirmatory
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neuropeptide Y receptor type 1 (CHEMBL4777)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 4.92 5.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1411397 1 5.15
CHEMBL1301994 1 5.14
CHEMBL1572588 1 5.13
CHEMBL1312767 1 5.01
CHEMBL1538224 1 4.93
CHEMBL1519588 1 4.87
CHEMBL526034 1 4.83
CHEMBL1567983 1 4.81
CHEMBL1560379 1 4.73
CHEMBL1465891 1 4.56
CHEMBL1603946 1 -
CHEMBL1538198 1 -
CHEMBL1422262 1 -
CHEMBL1383943 1 -
CHEMBL1448647 1 -
CHEMBL1376325 1 -
CHEMBL1979957 1 -
CHEMBL1482965 1 -
CHEMBL1534392 1 -
CHEMBL1986557 1 -
CHEMBL1406003 1 -
CHEMBL1471980 1 -
CHEMBL1597558 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1411397 EC50 = 7050.0 nM 5.15
CHEMBL1301994 EC50 = 7164.0 nM 5.14
CHEMBL1572588 EC50 = 7410.0 nM 5.13
CHEMBL1312767 EC50 = 9709.0 nM 5.01
CHEMBL1538224 EC50 = 11619.0 nM 4.93
CHEMBL1519588 EC50 = 13550.0 nM 4.87
CHEMBL526034 EC50 = 14724.0 nM 4.83
CHEMBL1567983 EC50 = 15631.0 nM 4.81
CHEMBL1560379 EC50 = 18494.0 nM 4.73
CHEMBL1465891 EC50 = 27316.0 nM 4.56
CHEMBL1603946 EC50 > 35430.0 nM -
CHEMBL1538198 EC50 > 35430.0 nM -
CHEMBL1422262 EC50 > 35430.0 nM -
CHEMBL1383943 EC50 > 35430.0 nM -
CHEMBL1448647 EC50 > 35430.0 nM -
CHEMBL1376325 EC50 > 35430.0 nM -
CHEMBL1979957 EC50 > 11810.0 nM -
CHEMBL1482965 EC50 > 35430.0 nM -
CHEMBL1534392 EC50 > 35430.0 nM -
CHEMBL1986557 EC50 > 3937.0 nM -
CHEMBL1406003 EC50 > 35430.0 nM -
CHEMBL1471980 EC50 > 35430.0 nM -
CHEMBL1597558 EC50 > 35430.0 nM -