Assay Detail
Binding
CHEMBL1614490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). (Class of assay: confirmatory) [Related pubchem assays: 2129 (Screening assay (BCLXL inhibitors).), 2057 (Screening assay (MCL-1 inhibitors).), 2144 (Summary AID.), 2166 (Screening assay (BCLXL inhibitors).)]
128
Total Activities
128
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 128 | 4.41 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1966952 | — | — | 1 | 5.14 |
| CHEMBL1307648 | — | — | 1 | 4.81 |
| CHEMBL1359782 | — | — | 1 | 4.75 |
| CHEMBL1453409 | — | — | 1 | 4.67 |
| CHEMBL1200938 | METHYSERGIDE MALEATE | 4.0 | 1 | 4.64 |
| CHEMBL1592276 | — | — | 1 | 4.60 |
| CHEMBL1401406 | — | — | 1 | 4.57 |
| CHEMBL1579209 | — | — | 1 | 4.56 |
| CHEMBL1316816 | — | — | 1 | 4.52 |
| CHEMBL1538897 | — | — | 1 | 4.49 |
| CHEMBL119171 | — | — | 1 | 4.47 |
| CHEMBL1543134 | — | — | 1 | 4.43 |
| CHEMBL1417070 | — | — | 1 | 4.29 |
| CHEMBL469424 | ASTERRIC ACID | — | 1 | 4.27 |
| CHEMBL578585 | — | — | 1 | 4.27 |
| CHEMBL3197662 | — | — | 1 | 4.26 |
| CHEMBL1451039 | — | — | 1 | 4.22 |
| CHEMBL1490685 | — | — | 1 | 4.20 |
| CHEMBL1312212 | — | — | 1 | 4.19 |
| CHEMBL1574133 | — | — | 1 | 4.18 |
| CHEMBL1543965 | — | — | 1 | 4.16 |
| CHEMBL1465739 | — | — | 1 | 4.04 |
| CHEMBL1417701 | — | — | 1 | 4.03 |
| CHEMBL1413866 | — | — | 1 | 4.02 |
| CHEMBL1319129 | — | — | 1 | - |
| CHEMBL1419305 | — | — | 1 | - |
| CHEMBL1435948 | — | — | 1 | - |
| CHEMBL1299990 | — | — | 1 | - |
| CHEMBL3199337 | — | — | 1 | - |
| CHEMBL1576140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1966952 | — | IC50 | = | 7216.0 | nM | 5.14 |
| CHEMBL1307648 | — | IC50 | = | 15508.0 | nM | 4.81 |
| CHEMBL1359782 | — | IC50 | = | 17627.0 | nM | 4.75 |
| CHEMBL1453409 | — | IC50 | = | 21291.0 | nM | 4.67 |
| CHEMBL1200938 | METHYSERGIDE MALEATE | IC50 | = | 22633.0 | nM | 4.64 |
| CHEMBL1592276 | — | IC50 | = | 25257.0 | nM | 4.60 |
| CHEMBL1401406 | — | IC50 | = | 27252.0 | nM | 4.57 |
| CHEMBL1579209 | — | IC50 | = | 27638.0 | nM | 4.56 |
| CHEMBL1316816 | — | IC50 | = | 30364.0 | nM | 4.52 |
| CHEMBL1538897 | — | IC50 | = | 32193.0 | nM | 4.49 |
| CHEMBL119171 | — | IC50 | = | 34008.0 | nM | 4.47 |
| CHEMBL1543134 | — | IC50 | = | 37072.0 | nM | 4.43 |
| CHEMBL1417070 | — | IC50 | = | 50793.0 | nM | 4.29 |
| CHEMBL578585 | — | IC50 | = | 53204.0 | nM | 4.27 |
| CHEMBL469424 | ASTERRIC ACID | IC50 | = | 54218.0 | nM | 4.27 |
| CHEMBL3197662 | — | IC50 | = | 55186.0 | nM | 4.26 |
| CHEMBL1451039 | — | IC50 | = | 60566.0 | nM | 4.22 |
| CHEMBL1490685 | — | IC50 | = | 63255.0 | nM | 4.20 |
| CHEMBL1312212 | — | IC50 | = | 64877.0 | nM | 4.19 |
| CHEMBL1574133 | — | IC50 | = | 65648.0 | nM | 4.18 |
| CHEMBL1543965 | — | IC50 | = | 68732.0 | nM | 4.16 |
| CHEMBL1465739 | — | IC50 | = | 90143.0 | nM | 4.04 |
| CHEMBL1417701 | — | IC50 | = | 93316.0 | nM | 4.03 |
| CHEMBL1413866 | — | IC50 | = | 96489.0 | nM | 4.02 |
| CHEMBL1365170 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1387693 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1348273 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1427879 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1308606 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1488981 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL165064 | ISOKAEMPFERIDE | IC50 | > | 108803.0 | nM | - |
| CHEMBL1510117 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1446458 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1311053 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1312353 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1449836 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1978364 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL11875 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1337575 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1482959 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1377223 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1465511 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1315784 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1416189 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1449253 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1336615 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL3193581 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL3192011 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL2007178 | — | IC50 | > | 108803.0 | nM | - |
| CHEMBL1503852 | — | IC50 | > | 108803.0 | nM | - |