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Assay Detail

CHEMBL1614499

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)]
ChEMBL ↗
1132
Total Activities
1132
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type BJ
Category confirmatory
Confidence 1 — Organism
Curated By Autocuration

Target

BJ (CHEMBL614358) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1132 5.38 6.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1349116 — — 1 6.90
CHEMBL486504 N-ACETYLCOLCHINOL -1.0 1 6.84
CHEMBL1607 TOPOTECAN HYDROCHLORIDE 4.0 1 6.80
CHEMBL1467533 — — 1 6.78
CHEMBL1545099 — — 1 6.67
CHEMBL1451921 — — 1 6.64
CHEMBL1505209 — — 1 6.61
CHEMBL87 — — 1 6.60
CHEMBL1476215 — — 1 6.55
CHEMBL1521217 — — 1 6.55
CHEMBL31840 — — 1 6.53
CHEMBL1523841 — — 1 6.50
CHEMBL1376166 — — 1 6.47
CHEMBL1586733 — — 1 6.46
CHEMBL1359872 — — 1 6.46
CHEMBL587994 — — 1 6.46
CHEMBL1462630 — — 1 6.45
CHEMBL1424468 — — 1 6.45
CHEMBL1386228 — — 1 6.45
CHEMBL1200563 CERIVASTATIN SODIUM 4.0 1 6.45
CHEMBL1418095 — — 1 6.44
CHEMBL3196518 — — 1 6.43
CHEMBL1324197 — — 1 6.42
CHEMBL1592124 — — 1 6.42
CHEMBL1490339 — — 1 6.41
CHEMBL1588661 — — 1 6.41
CHEMBL1342029 — — 1 6.40
CHEMBL1572746 — — 1 6.40
CHEMBL1582760 — — 1 6.40
CHEMBL1405453 — — 1 6.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1349116 — EC50 = 127.0 nM 6.90
CHEMBL486504 N-ACETYLCOLCHINOL EC50 = 146.0 nM 6.84
CHEMBL1607 TOPOTECAN HYDROCHLORIDE EC50 = 159.0 nM 6.80
CHEMBL1467533 — EC50 = 165.0 nM 6.78
CHEMBL1545099 — EC50 = 216.0 nM 6.67
CHEMBL1451921 — EC50 = 229.0 nM 6.64
CHEMBL1505209 — EC50 = 246.0 nM 6.61
CHEMBL87 — EC50 = 249.0 nM 6.60
CHEMBL1476215 — EC50 = 284.0 nM 6.55
CHEMBL1521217 — EC50 = 279.0 nM 6.55
CHEMBL31840 — EC50 = 297.0 nM 6.53
CHEMBL1523841 — EC50 = 318.0 nM 6.50
CHEMBL1376166 — EC50 = 338.0 nM 6.47
CHEMBL1586733 — EC50 = 349.0 nM 6.46
CHEMBL1359872 — EC50 = 346.0 nM 6.46
CHEMBL587994 — EC50 = 343.0 nM 6.46
CHEMBL1424468 — EC50 = 354.0 nM 6.45
CHEMBL1462630 — EC50 = 357.0 nM 6.45
CHEMBL1386228 — EC50 = 353.0 nM 6.45
CHEMBL1200563 CERIVASTATIN SODIUM EC50 = 356.0 nM 6.45
CHEMBL1418095 — EC50 = 365.0 nM 6.44
CHEMBL3196518 — EC50 = 370.0 nM 6.43
CHEMBL1592124 — EC50 = 385.0 nM 6.42
CHEMBL1324197 — EC50 = 380.0 nM 6.42
CHEMBL1588661 — EC50 = 386.0 nM 6.41
CHEMBL1490339 — EC50 = 388.0 nM 6.41
CHEMBL1342029 — EC50 = 396.0 nM 6.40
CHEMBL1405453 — EC50 = 401.0 nM 6.40
CHEMBL1513325 — EC50 = 396.0 nM 6.40
CHEMBL1582760 — EC50 = 396.0 nM 6.40
CHEMBL1572746 — EC50 = 399.0 nM 6.40
CHEMBL1990919 — EC50 = 421.0 nM 6.38
CHEMBL1408486 — EC50 = 420.0 nM 6.38
CHEMBL1316978 — EC50 = 432.0 nM 6.37
CHEMBL1602637 — EC50 = 428.0 nM 6.37
CHEMBL1544445 — EC50 = 428.0 nM 6.37
CHEMBL1560237 — EC50 = 434.0 nM 6.36
CHEMBL1362687 — EC50 = 434.0 nM 6.36
CHEMBL1997171 — EC50 = 435.0 nM 6.36
CHEMBL1383090 — EC50 = 442.0 nM 6.36
CHEMBL1481538 — EC50 = 441.0 nM 6.36
CHEMBL1392527 — EC50 = 455.0 nM 6.34
CHEMBL1374715 — EC50 = 460.0 nM 6.34
CHEMBL290077 — EC50 = 460.0 nM 6.34
CHEMBL1544633 — EC50 = 457.0 nM 6.34
CHEMBL1998716 — EC50 = 472.0 nM 6.33
CHEMBL1539486 — EC50 = 469.0 nM 6.33
CHEMBL1333449 — EC50 = 464.0 nM 6.33
CHEMBL1372163 — EC50 = 479.0 nM 6.32
CHEMBL1576251 — EC50 = 498.0 nM 6.30