Assay Detail
Functional
CHEMBL1614503
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PUBCHEM_BIOASSAY: Colorimetric assay for HTS discovery of chemical inhibitors of EphA4 receptor antagonists. Secondary screen (Class of assay: confirmatory)
134
Total Activities
134
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 134 | 5.13 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1331573 | — | — | 1 | 6.52 |
| CHEMBL1461953 | — | — | 1 | 6.40 |
| CHEMBL1471965 | — | — | 1 | 6.22 |
| CHEMBL1531566 | — | — | 1 | 5.92 |
| CHEMBL1305648 | — | — | 1 | 5.87 |
| CHEMBL1606403 | — | — | 1 | 5.84 |
| CHEMBL3196667 | — | — | 1 | 5.83 |
| CHEMBL1464392 | — | — | 1 | 5.81 |
| CHEMBL1300494 | — | — | 1 | 5.75 |
| CHEMBL1468811 | — | — | 1 | 5.70 |
| CHEMBL1329962 | — | — | 1 | 5.65 |
| CHEMBL1471612 | — | — | 1 | 5.64 |
| CHEMBL1371777 | — | — | 1 | 5.61 |
| CHEMBL1351799 | — | — | 1 | 5.60 |
| CHEMBL1444164 | — | — | 1 | 5.58 |
| CHEMBL255881 | — | — | 1 | 5.55 |
| CHEMBL1348438 | — | — | 1 | 5.54 |
| CHEMBL1420591 | — | — | 1 | 5.50 |
| CHEMBL1605099 | — | — | 1 | 5.49 |
| CHEMBL3392071 | — | — | 1 | 5.48 |
| CHEMBL1581585 | — | — | 1 | 5.46 |
| CHEMBL1362566 | — | — | 1 | 5.45 |
| CHEMBL1347956 | — | — | 1 | 5.45 |
| CHEMBL1351212 | — | — | 1 | 5.39 |
| CHEMBL1544265 | — | — | 1 | 5.33 |
| CHEMBL1521960 | — | — | 1 | 5.30 |
| CHEMBL1442729 | — | — | 1 | 5.29 |
| CHEMBL1308747 | — | — | 1 | 5.29 |
| CHEMBL1340514 | — | — | 1 | 5.28 |
| CHEMBL257359 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1331573 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1461953 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1471965 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1531566 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1305648 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL1606403 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL3196667 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL1464392 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL1300494 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL1468811 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL1329962 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL1471612 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1371777 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL1351799 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL1444164 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL255881 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL1348438 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL1420591 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL1605099 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL3392071 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL1581585 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL1362566 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL1347956 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL1351212 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1544265 | — | IC50 | = | 4620.0 | nM | 5.33 |
| CHEMBL1521960 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL1442729 | — | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL1308747 | — | IC50 | = | 5140.0 | nM | 5.29 |
| CHEMBL1340514 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL257359 | — | IC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL1483471 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL1492819 | — | IC50 | = | 5450.0 | nM | 5.26 |
| CHEMBL1336938 | — | IC50 | = | 5650.0 | nM | 5.25 |
| CHEMBL1390056 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL1326167 | — | IC50 | = | 6730.0 | nM | 5.17 |
| CHEMBL1540929 | — | IC50 | = | 6770.0 | nM | 5.17 |
| CHEMBL1903510 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL1539325 | — | IC50 | = | 8980.0 | nM | 5.05 |
| CHEMBL1426947 | — | IC50 | = | 9050.0 | nM | 5.04 |
| CHEMBL1384420 | — | IC50 | = | 9810.0 | nM | 5.01 |
| CHEMBL1612672 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL1559707 | — | IC50 | = | 9880.0 | nM | 5.00 |
| CHEMBL1457774 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1564047 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL1370844 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL1446668 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL1300534 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1423135 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1391256 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL1385602 | — | IC50 | = | 12000.0 | nM | 4.92 |