Assay Detail
Functional
CHEMBL1633579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Vaccinia virus WR infected in HFF assessed as inhibition of DNA synthesis after 24 hrs by PCR analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.50 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1631219 | — | — | 1 | 6.22 |
| CHEMBL788 | IDOXURIDINE | 4.0 | 1 | 4.77 |
| CHEMBL1257073 | TECOVIRIMAT | 4.0 | 1 | - |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1631219 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL788 | IDOXURIDINE | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1257073 | TECOVIRIMAT | EC50 | > | 100000.0 | nM | - |
| CHEMBL5314375 | CIDOFOVIR | EC50 | - | — | - |