Assay Detail
ADMET
CHEMBL1633588
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Antiproliferative activity against HFF after 3 days by coulter counter assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.90 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1631218 | — | — | 1 | 6.85 |
| CHEMBL1629730 | — | — | 1 | 6.70 |
| CHEMBL1631221 | THIARABINE | 1.0 | 1 | 6.00 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.72 |
| CHEMBL1631219 | — | — | 1 | 5.52 |
| CHEMBL1631220 | — | — | 1 | 4.58 |
| CHEMBL1631222 | — | — | 1 | - |
| CHEMBL445596 | 4'-THIOTHYMIDINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1631218 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1629730 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1631221 | THIARABINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5314375 | CIDOFOVIR | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1631219 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1631220 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1631222 | — | IC50 | < | 30.0 | nM | - |
| CHEMBL445596 | 4'-THIOTHYMIDINE | IC50 | < | 30.0 | nM | - |