Assay Detail
Binding
CHEMBL1634174
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Inhibition of Wistar rat lenses ALR2 by spectrophotometry
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Lens of camera-type eye |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Acetic acid derivatives of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide as a novel class of potent aldose reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.51 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | 2.0 | 1 | 7.54 |
| CHEMBL1632036 | — | — | 1 | 7.50 |
| CHEMBL1632033 | — | — | 1 | 7.39 |
| CHEMBL1632040 | — | — | 1 | 7.28 |
| CHEMBL1632032 | — | — | 1 | 7.18 |
| CHEMBL1632037 | — | — | 1 | 7.15 |
| CHEMBL1632029 | — | — | 1 | 7.05 |
| CHEMBL1632034 | — | — | 1 | 7.03 |
| CHEMBL1632030 | — | — | 1 | 6.97 |
| CHEMBL1632027 | — | — | 1 | 6.96 |
| CHEMBL1632038 | — | — | 1 | 6.94 |
| CHEMBL1632024 | — | — | 1 | 6.90 |
| CHEMBL1632025 | — | — | 1 | 6.66 |
| CHEMBL1632035 | — | — | 1 | 6.22 |
| CHEMBL1632039 | — | — | 1 | 6.17 |
| CHEMBL1632031 | — | — | 1 | 6.03 |
| CHEMBL1632026 | — | — | 1 | 6.01 |
| CHEMBL1632044 | — | — | 1 | 4.85 |
| CHEMBL1632041 | — | — | 1 | 4.23 |
| CHEMBL1632042 | — | — | 1 | 4.13 |
| CHEMBL1632028 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1632036 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1632033 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1632040 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1632032 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1632037 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1632029 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1632034 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL1632030 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL1632027 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL1632038 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1632024 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL1632025 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL1632035 | — | IC50 | = | 595.0 | nM | 6.22 |
| CHEMBL1632039 | — | IC50 | = | 674.0 | nM | 6.17 |
| CHEMBL1632031 | — | IC50 | = | 931.0 | nM | 6.03 |
| CHEMBL1632026 | — | IC50 | = | 975.0 | nM | 6.01 |
| CHEMBL1632044 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1632041 | — | IC50 | = | 58400.0 | nM | 4.23 |
| CHEMBL1632042 | — | IC50 | = | 74500.0 | nM | 4.13 |
| CHEMBL1632028 | — | IC50 | = | 101500.0 | nM | - |