Assay Detail
Binding
CHEMBL1634345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H[AMPA from rat recombinant GluA3o expressed in sS9 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | sS9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.92 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276815 | (S)-AMPA | — | 1 | 7.68 |
| CHEMBL2092841 | — | — | 1 | 6.08 |
| CHEMBL154535 | — | — | 1 | 5.34 |
| CHEMBL72366 | — | — | 1 | 4.56 |
| CHEMBL30285 | IBOTENIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276815 | (S)-AMPA | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL2092841 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL154535 | — | Ki | = | 4520.0 | nM | 5.34 |
| CHEMBL72366 | — | Ki | = | 27500.0 | nM | 4.56 |
| CHEMBL30285 | IBOTENIC ACID | Ki | > | 100000.0 | nM | - |