Glutamate receptor 3 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P19492. Use UniProt P19492 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P19492 as the stable identity anchor, then attach disease evidence before program review.
Glutamate receptor 3
Review this target as Glutamate receptor 3, mapped to UniProt P19492. Sequence length is 888 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glutamate receptor 3 as ChEMBL target CHEMBL3504, mapped to UniProt P19492. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Glutamate receptor 3 is the right protein anchor across sources, using UniProt P19492 as the stable mapping.
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| Preferred Name | Glutamate receptor 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P19492 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutamate receptor 3 |
| UniProt Accession | P19492 |
| Component Type | Protein |
| Sequence Length | 888 aa |
Glutamate receptor 3
Review this target as Glutamate receptor 3, mapped to UniProt P19492. Sequence length is 888 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL13378 | 10.68 | Ki | 0.021 | Preclinical |
| CHEMBL370941 | 10.35 | Ki | 0.045 | Preclinical |
| CHEMBL388746 | 9.41 | Ki | 0.39 | Preclinical |
| CHEMBL372643 | 8.92 | Ki | 1.2 | Preclinical |
| CHEMBL94859 | 8.66 | Ki | 2.2 | Preclinical |
| CHEMBL193087 | 8.43 | Ki | 3.7 | Preclinical |
| CHEMBL276815 | 7.68 | Ki | 21.0 | Preclinical |
| CHEMBL1096289 | 7.19 | IC50 | 64.0 | Preclinical |
| CHEMBL123132 | 7.16 | Ki | 70.0 | Preclinical |
| CHEMBL12442 | 7.0 | EC50 | 100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 20 | 44 | 6.0 |
| single protein format | 4 | 3 | 5.9 |
| assay format | 1 | 1 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 14 | 15 | 5.0 |