Compound Detail
CHEMBL1096289
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Basic Information
| ChEMBL ID | CHEMBL1096289 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GLVZEIGFWZGDFV-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
334.5
MW (Da)
1.43
ALogP
4
HBA
4
HBD
79.2
PSA (Ų)
0.37
QED
0
Ro5 Violations
15
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor 3 CHEMBL3504 | IC50 | 7.19 | 7.19 | 64.0 | 1 |
| Glutamate receptor 4 CHEMBL3505 | IC50 | 6.5 | 6.5 | 320.0 | 1 |
| Glutamate receptor 1 CHEMBL3753 | IC50 | 6.34 | 6.34 | 460.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 3 | IC50 | = | 64.0 | nM | 7.19 | Inhibition of rat recombinant GluA3 receptor expressed in Xenopus oocytes assess... | 20096591 |
| Glutamate receptor 4 | IC50 | = | 320.0 | nM | 6.5 | Inhibition of rat recombinant GluA4 receptor expressed in Xenopus oocytes assess... | 20096591 |
| Glutamate receptor 1 | IC50 | = | 460.0 | nM | 6.34 | Inhibition of rat recombinant GluA1 receptor expressed in Xenopus oocytes assess... | 20096591 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20096591 | 10.1016/j.bmc.2009.12.072 | Unchecked | 2 |
| 20096591 | 10.1016/j.bmc.2009.12.072 | Glutamate receptor 1 | 1 |
| 20096591 | 10.1016/j.bmc.2009.12.072 | Glutamate receptor 3 | 1 |
| 20096591 | 10.1016/j.bmc.2009.12.072 | Glutamate receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine