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Assay Detail

CHEMBL1108954

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat recombinant GluA3 receptor expressed in Xenopus oocytes assessed as inhibition of 300 uM kainate-induced current
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Cell Type Oocyte
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glutamate receptor 3 (CHEMBL3504)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.
Fleming JJ, England PM.
Bioorg Med Chem (2010) 18 : 1381 -1387
PubMed 20096591 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.19 7.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1096289 1 7.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1096289 IC50 = 64.0 nM 7.19