Glutamate receptor 4 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P19493. Use UniProt P19493 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P19493 as the stable identity anchor, then attach disease evidence before program review.
Glutamate receptor 4
Review this target as Glutamate receptor 4, mapped to UniProt P19493. Sequence length is 902 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glutamate receptor 4 as ChEMBL target CHEMBL3505, mapped to UniProt P19493. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Glutamate receptor 4 is the right protein anchor across sources, using UniProt P19493 as the stable mapping.
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| Preferred Name | Glutamate receptor 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P19493 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutamate receptor 4 |
| UniProt Accession | P19493 |
| Component Type | Protein |
| Sequence Length | 902 aa |
Glutamate receptor 4
Review this target as Glutamate receptor 4, mapped to UniProt P19493. Sequence length is 902 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL13378 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL370941 | 10.36 | Ki | 0.044 | Preclinical |
| CHEMBL388746 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL372643 | 9.14 | Ki | 0.73 | Preclinical |
| CHEMBL193087 | 8.62 | Ki | 2.4 | Preclinical |
| CHEMBL94859 | 8.57 | Ki | 2.7 | Preclinical |
| CHEMBL276815 | 7.4 | Ki | 40.0 | Preclinical |
| CHEMBL4756304 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL123132 | 6.91 | Ki | 123.0 | Preclinical |
| CHEMBL351031 | 6.89 | IC50 | 130.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 18 | 35 | 6.2 |
| subcellular format | 4 | 5 | 6.0 |
| assay format | 2 | 2 | 5.9 |
| cell membrane format | 1 | 5 | 5.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 11 | 11 | 4.6 |