Compound Detail
CHEMBL351031
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Basic Information
| ChEMBL ID | CHEMBL351031 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JSMYHXFFKXKZRN-SBMIAAHKSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
265.3
MW (Da)
0.62
ALogP
4
HBA
4
HBD
106.9
PSA (Ų)
0.64
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.24 | 7.24 | 58.0 | 1 |
| Glutamate receptor 4 CHEMBL3505 | IC50 | 6.89 | 6.89 | 130.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 58.0 | nM | 7.24 | Displacement of [3H]-Kainic acid from KA in rat synaptic membrane | 39133077 |
| Glutamate receptor 4 | IC50 | = | 130.0 | nM | 6.89 | Displacement of [3H]-AMPA from AMPA in rat synaptic membrane | 39133077 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(00)80404-7 | Rattus norvegicus | 1 |
| 39133077 | 10.1021/acs.jmedchem.4c01311 | Glutamate receptor 4 | 1 |
| 39133077 | 10.1021/acs.jmedchem.4c01311 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine