Assay Detail
Binding
CHEMBL5579283
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Displacement of [3H]-AMPA from AMPA in rat synaptic membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Synaptosome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.54 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4756304 | — | — | 1 | 7.22 |
| CHEMBL351031 | — | — | 1 | 6.89 |
| CHEMBL1232313 | DOMOIC ACID | — | 1 | 6.33 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4756304 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL351031 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1232313 | DOMOIC ACID | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL275040 | KAINIC ACID | IC50 | = | 1900.0 | nM | 5.72 |