Compound Detail
CHEMBL4756304
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4756304 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CWXNEBSQRIECMV-PJKMHFRUSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
310.3
MW (Da)
-0.70
ALogP
5
HBA
5
HBD
156.8
PSA (Ų)
0.48
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor 4 CHEMBL3505 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.48 | 6.48 | 330.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 4 | IC50 | = | 60.0 | nM | 7.22 | Displacement of [3H]-AMPA from AMPA in rat synaptic membrane | 39133077 |
| Unchecked | IC50 | = | 330.0 | nM | 6.48 | Displacement of [3H]-Kainic acid from KA in rat synaptic membrane | 39133077 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33120080 | 10.1016/j.bmc.2020.115820 | ADMET | 3 |
| 39133077 | 10.1021/acs.jmedchem.4c01311 | Glutamate receptor 4 | 1 |
| 39133077 | 10.1021/acs.jmedchem.4c01311 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine