Assay Detail
Functional
CHEMBL1635108
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Antiviral activity against HIV1 3B infected in human MT-2 cells by two fold dilution method in presence of 10% FBS, HSA and alpha1-AGP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.64 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513189 | — | — | 1 | 7.82 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 7.75 |
| CHEMBL408699 | — | — | 1 | 7.62 |
| CHEMBL414850 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513189 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL408699 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL414850 | — | EC50 | = | 43.0 | nM | 7.37 |