Assay Detail
Functional
CHEMBL1635112
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Antiviral activity against HIV1 3B infected in human MT-4 cells by two fold dilution method in presence of 10% FBS
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.86 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408699 | — | — | 1 | 9.77 |
| CHEMBL513189 | — | — | 1 | 9.15 |
| CHEMBL414850 | — | — | 1 | 8.40 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408699 | — | EC50 | = | 0.17 | nM | 9.77 |
| CHEMBL513189 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL414850 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL254316 | RALTEGRAVIR | EC50 | = | 8.0 | nM | 8.10 |