Assay Detail
Functional
CHEMBL1635610
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL4-3 infected in human TZM-bl cells after 4 days by luciferase reporter gene assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 7.85 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1632241 | — | — | 1 | 9.42 |
| CHEMBL1632238 | — | — | 1 | 9.26 |
| CHEMBL569259 | — | — | 1 | 9.17 |
| CHEMBL1632236 | — | — | 1 | 9.15 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.85 |
| CHEMBL1632234 | — | — | 1 | 8.71 |
| CHEMBL1632242 | — | — | 1 | 8.37 |
| CHEMBL1629741 | — | — | 1 | 8.20 |
| CHEMBL1632226 | — | — | 1 | 8.16 |
| CHEMBL1632205 | — | — | 1 | 8.14 |
| CHEMBL1632235 | — | — | 1 | 8.10 |
| CHEMBL1632230 | — | — | 1 | 8.00 |
| CHEMBL1632237 | — | — | 1 | 7.98 |
| CHEMBL1632233 | — | — | 1 | 7.61 |
| CHEMBL1632224 | — | — | 1 | 7.30 |
| CHEMBL1632228 | — | — | 1 | 7.04 |
| CHEMBL1632240 | — | — | 1 | 7.01 |
| CHEMBL1632239 | — | — | 1 | 6.84 |
| CHEMBL1632229 | — | — | 1 | 6.51 |
| CHEMBL1632232 | — | — | 1 | 6.22 |
| CHEMBL1632231 | — | — | 1 | 4.83 |
| CHEMBL1632227 | — | — | 1 | - |
| CHEMBL1632225 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1632241 | — | EC50 | = | 0.38 | nM | 9.42 |
| CHEMBL1632238 | — | EC50 | = | 0.55 | nM | 9.26 |
| CHEMBL569259 | — | EC50 | = | 0.68 | nM | 9.17 |
| CHEMBL1632236 | — | EC50 | = | 0.71 | nM | 9.15 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1632234 | — | EC50 | = | 1.95 | nM | 8.71 |
| CHEMBL1632242 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1629741 | — | EC50 | = | 6.33 | nM | 8.20 |
| CHEMBL1632226 | — | EC50 | = | 6.89 | nM | 8.16 |
| CHEMBL1632205 | — | EC50 | = | 7.29 | nM | 8.14 |
| CHEMBL1632235 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1632230 | — | EC50 | = | 10.1 | nM | 8.00 |
| CHEMBL1632237 | — | EC50 | = | 10.4 | nM | 7.98 |
| CHEMBL1632233 | — | EC50 | = | 24.4 | nM | 7.61 |
| CHEMBL1632224 | — | EC50 | = | 50.2 | nM | 7.30 |
| CHEMBL1632228 | — | EC50 | = | 91.2 | nM | 7.04 |
| CHEMBL1632240 | — | EC50 | = | 97.1 | nM | 7.01 |
| CHEMBL1632239 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL1632229 | — | EC50 | = | 308.0 | nM | 6.51 |
| CHEMBL1632232 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1632231 | — | EC50 | = | 14920.0 | nM | 4.83 |
| CHEMBL1632227 | — | EC50 | > | 47170.0 | nM | - |
| CHEMBL1632225 | — | EC50 | - | — | - |