Assay Detail
Functional
CHEMBL1635618
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against multidrug resistant HIV1 A17 containing reverse transcripatseK103N and Y181C mutation infected in human MT2 cells assessed as reduction in p24 antigen level after 4 days by ELISA
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.15 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1632241 | — | — | 1 | 7.02 |
| CHEMBL569051 | — | — | 1 | 6.70 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 6.48 |
| CHEMBL569259 | — | — | 1 | 6.41 |
| CHEMBL1632238 | — | — | 1 | 6.22 |
| CHEMBL1632236 | — | — | 1 | 6.14 |
| CHEMBL1632228 | — | — | 1 | 5.84 |
| CHEMBL569258 | — | — | 1 | 5.71 |
| CHEMBL1632242 | — | — | 1 | 5.52 |
| CHEMBL1632205 | — | — | 1 | 5.46 |
| CHEMBL1632235 | — | — | 1 | - |
| CHEMBL1632234 | — | — | 1 | - |
| CHEMBL1632237 | — | — | 1 | - |
| CHEMBL566152 | — | — | 1 | - |
| CHEMBL1632226 | — | — | 1 | - |
| CHEMBL1632224 | — | — | 1 | - |
| CHEMBL569494 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1632241 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL569051 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL569259 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1632238 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1632236 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL1632228 | — | EC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL569258 | — | EC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL1632242 | — | EC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL1632205 | — | EC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL1632235 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1632234 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1632237 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL566152 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1632226 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1632224 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL569494 | — | EC50 | > | 10000.0 | nM | - |