Assay Detail
Functional
CHEMBL1637002
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Antiviral activity against J2R gene deficient Vaccinia virus harboring VVTK::luc infected in HFF assessed as reduction of plaque formation after 3 days
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.57 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1631219 | — | — | 1 | 6.52 |
| CHEMBL788 | IDOXURIDINE | 4.0 | 1 | 5.15 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.03 |
| CHEMBL1257073 | TECOVIRIMAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1631219 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL788 | IDOXURIDINE | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL1257073 | TECOVIRIMAT | EC50 | - | — | - |