Assay Detail
Binding
CHEMBL1637647
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Inhibition of Mycobacterium tuberculosis Thymidine monophosphate kinase by spectrophotometry
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.90 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1632626 | — | — | 1 | 6.57 |
| CHEMBL1631399 | — | — | 1 | 6.52 |
| CHEMBL1632625 | — | — | 1 | 6.38 |
| CHEMBL1631398 | — | — | 1 | 6.24 |
| CHEMBL1631395 | — | — | 1 | 6.03 |
| CHEMBL1632627 | — | — | 1 | 5.94 |
| CHEMBL1631397 | — | — | 1 | 5.61 |
| CHEMBL394429 | THYMIDINE MONOPHOSPHATE | — | 1 | 5.35 |
| CHEMBL1631396 | — | — | 1 | 5.24 |
| CHEMBL1631394 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1632626 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL1631399 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL1632625 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL1631398 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL1631395 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL1632627 | — | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL1631397 | — | Ki | = | 2460.0 | nM | 5.61 |
| CHEMBL394429 | THYMIDINE MONOPHOSPHATE | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL1631396 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL1631394 | — | Ki | = | 7070.0 | nM | 5.15 |