Assay Detail
Binding
CHEMBL1638239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium smegmatis MC2 155 ATP synthase subunit c-mediated ATP production
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycolicibacterium smegmatis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Putative uncharacterized protein atpE (CHEMBL1641346) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium smegmatis |
Publication
Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376488 | BEDAQUILINE | 4.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376488 | BEDAQUILINE | IC50 | = | 10.0 | nM | 8.00 |