Assay Detail
Functional
CHEMBL1638849
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human histamine H3 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histamine H4 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 7.87 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18661 | IMMEPIP | — | 1 | 10.40 |
| CHEMBL19010 | IODOPROXYFAN | — | 1 | 10.30 |
| CHEMBL19439 | IMETIT | — | 1 | 9.90 |
| CHEMBL82298 | IMMETHRIDINE | — | 1 | 9.80 |
| CHEMBL268229 | — | — | 1 | 9.50 |
| CHEMBL175782 | METHIMEPIP | — | 1 | 9.50 |
| CHEMBL268490 | — | — | 1 | 9.40 |
| CHEMBL1632409 | CLOBENPROBIT | — | 1 | 9.40 |
| CHEMBL281576 | — | — | 1 | 9.30 |
| CHEMBL90019 | IMBUTAMINE | — | 1 | 9.20 |
| CHEMBL19173 | PROXYFAN | — | 1 | 8.50 |
| CHEMBL417096 | IMPENTAMINE | — | 1 | 8.40 |
| CHEMBL90 | HISTAMINE | 4.0 | 1 | 8.30 |
| CHEMBL11919 | — | — | 1 | 8.00 |
| CHEMBL91353 | HOMOHISTAMINE | — | 1 | 7.40 |
| CHEMBL106612 | IMIFURAMINE | — | 1 | 7.40 |
| CHEMBL106931 | — | — | 1 | 7.00 |
| CHEMBL105803 | — | — | 1 | 7.00 |
| CHEMBL320331 | — | — | 1 | 6.70 |
| CHEMBL1196470 | — | — | 1 | 6.50 |
| CHEMBL106913 | — | — | 1 | 6.10 |
| CHEMBL321920 | — | — | 1 | 6.10 |
| CHEMBL321860 | — | — | 1 | 5.50 |
| CHEMBL106158 | — | — | 1 | 5.00 |
| CHEMBL1632410 | — | — | 1 | 5.00 |
| CHEMBL322256 | — | — | 1 | 5.00 |
| CHEMBL106570 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18661 | IMMEPIP | EC50 | = | 0.03981 | nM | 10.40 |
| CHEMBL19010 | IODOPROXYFAN | EC50 | = | 0.05012 | nM | 10.30 |
| CHEMBL19439 | IMETIT | EC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL82298 | IMMETHRIDINE | EC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL268229 | — | EC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL175782 | METHIMEPIP | EC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL268490 | — | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL1632409 | CLOBENPROBIT | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL281576 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL90019 | IMBUTAMINE | EC50 | = | 0.631 | nM | 9.20 |
| CHEMBL19173 | PROXYFAN | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL417096 | IMPENTAMINE | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL90 | HISTAMINE | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL11919 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL91353 | HOMOHISTAMINE | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL106612 | IMIFURAMINE | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL106931 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL105803 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL320331 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL1196470 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL106913 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL321920 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL321860 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL106158 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1632410 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL322256 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL106570 | — | EC50 | > | 100000.0 | nM | - |