Assay Detail
Binding
CHEMBL1639366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]LY354740 from recombinant rat mGluR2 expressed in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 2 (CHEMBL2851) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.01 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261288 | — | — | 1 | 7.80 |
| CHEMBL411440 | — | — | 1 | 7.58 |
| CHEMBL401446 | — | — | 1 | 7.47 |
| CHEMBL394287 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261288 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL411440 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL401446 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL394287 | — | IC50 | = | 6400.0 | nM | 5.19 |