Assay Detail
Binding
CHEMBL1639902
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Inhibition of human COX1
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.10 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1232083 | — | — | 1 | 8.70 |
| CHEMBL1630251 | — | — | 1 | 6.46 |
| CHEMBL1630238 | — | — | 1 | 6.43 |
| CHEMBL1630249 | — | — | 1 | 6.36 |
| CHEMBL1288533 | — | — | 1 | 6.16 |
| CHEMBL1230348 | — | — | 1 | 6.16 |
| CHEMBL1230209 | TIGEMOCOXIB | 2.0 | 1 | 5.99 |
| CHEMBL1630257 | — | — | 1 | 5.79 |
| CHEMBL1630250 | — | — | 1 | 5.71 |
| CHEMBL1630253 | — | — | 1 | 5.44 |
| CHEMBL1630242 | — | — | 1 | 5.42 |
| CHEMBL1630232 | — | — | 1 | 5.13 |
| CHEMBL1630255 | — | — | 1 | 4.80 |
| CHEMBL1630254 | — | — | 1 | 4.65 |
| CHEMBL1630223 | — | — | 1 | 4.40 |
| CHEMBL1630258 | — | — | 1 | 4.38 |
| CHEMBL1630236 | — | — | 1 | 4.31 |
| CHEMBL1630233 | — | — | 1 | 4.18 |
| CHEMBL1630237 | — | — | 1 | 4.17 |
| CHEMBL1630244 | — | — | 1 | 4.00 |
| CHEMBL1630245 | — | — | 1 | 4.00 |
| CHEMBL1630246 | — | — | 1 | 4.00 |
| CHEMBL1630247 | — | — | 1 | 4.00 |
| CHEMBL1630243 | — | — | 1 | 4.00 |
| CHEMBL1630252 | — | — | 1 | 4.00 |
| CHEMBL1630256 | — | — | 1 | 4.00 |
| CHEMBL1630248 | — | — | 1 | - |
| CHEMBL1630241 | — | — | 1 | - |
| CHEMBL1630240 | — | — | 1 | - |
| CHEMBL1630239 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1232083 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1630251 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1630238 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1630249 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1288533 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1230348 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1230209 | TIGEMOCOXIB | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL1630257 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL1630250 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL1630253 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL1630242 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL1630232 | — | IC50 | = | 7440.0 | nM | 5.13 |
| CHEMBL1630255 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL1630254 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL1630223 | — | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL1630258 | — | IC50 | = | 41600.0 | nM | 4.38 |
| CHEMBL1630236 | — | IC50 | = | 48900.0 | nM | 4.31 |
| CHEMBL1630233 | — | IC50 | = | 66700.0 | nM | 4.18 |
| CHEMBL1630237 | — | IC50 | = | 68400.0 | nM | 4.17 |
| CHEMBL1630244 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1630245 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1630246 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1630247 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1630243 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1630252 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1630256 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1630248 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL1630241 | — | IC50 | < | 140.0 | nM | - |
| CHEMBL1630240 | — | IC50 | < | 140.0 | nM | - |
| CHEMBL1630239 | — | IC50 | < | 140.0 | nM | - |
| CHEMBL1630235 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1630234 | — | IC50 | > | 100000.0 | nM | - |