Assay Detail
Binding
CHEMBL1640839
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGF-induced EGFR phosphorylation in human CAL27 cells overexpressing EGFR after 16 hrs by Western blot
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CAL-27 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1630109 | — | — | 1 | 6.30 |
| CHEMBL1630107 | — | — | 1 | - |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1630109 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1630107 | — | IC50 | < | 32.0 | nM | - |
| CHEMBL554 | LAPATINIB | IC50 | < | 32.0 | nM | - |