Assay Detail
Binding
CHEMBL1640945
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Inhibition of recombinant MPO mediated taurine chlorination by microplate reader method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Urine |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-based design, synthesis, and pharmacological evaluation of 3-(aminoalkyl)-5-fluoroindoles as myeloperoxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.69 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1630742 | — | — | 1 | 8.10 |
| CHEMBL1630741 | — | — | 1 | 7.82 |
| CHEMBL1630731 | — | — | 1 | 7.40 |
| CHEMBL1630733 | — | — | 1 | 7.30 |
| CHEMBL1630729 | — | — | 1 | 7.05 |
| CHEMBL361949 | — | — | 1 | 6.89 |
| CHEMBL1630730 | — | — | 1 | 6.80 |
| CHEMBL1630736 | — | — | 1 | 6.77 |
| CHEMBL275628 | — | — | 1 | 6.70 |
| CHEMBL1630725 | — | — | 1 | 6.70 |
| CHEMBL1630732 | — | — | 1 | 6.70 |
| CHEMBL1630734 | — | — | 1 | 6.70 |
| CHEMBL1630723 | — | — | 1 | 6.70 |
| CHEMBL1630743 | — | — | 1 | 6.58 |
| CHEMBL1630726 | — | — | 1 | 6.52 |
| CHEMBL1630735 | — | — | 1 | 6.52 |
| CHEMBL1630739 | — | — | 1 | 6.50 |
| CHEMBL1630738 | — | — | 1 | 6.46 |
| CHEMBL1630740 | — | — | 1 | 6.46 |
| CHEMBL1630727 | — | — | 1 | 6.10 |
| CHEMBL1630722 | — | — | 1 | 6.05 |
| CHEMBL1630724 | — | — | 1 | 6.00 |
| CHEMBL1630728 | — | — | 1 | 5.99 |
| CHEMBL1630737 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1630742 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1630741 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1630731 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1630733 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1630729 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL361949 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1630730 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1630736 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL275628 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1630725 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1630732 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1630734 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1630723 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1630743 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1630726 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1630735 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1630739 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1630738 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1630740 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1630727 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1630722 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1630724 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1630728 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1630737 | — | IC50 | = | 1500.0 | nM | 5.82 |