Assay Detail
Binding
CHEMBL1645642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine brain tubulin polymerization by microtubule assembly assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.68 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643765 | 11-EPI-TUBULYSIN D | — | 1 | 5.85 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 5.80 |
| CHEMBL1643766 | 13-EPI-TUBULYSIN D | — | 1 | 5.77 |
| CHEMBL455213 | TUBULYSIN D | — | 1 | 5.77 |
| CHEMBL1643767 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643765 | 11-EPI-TUBULYSIN D | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1643766 | 13-EPI-TUBULYSIN D | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL455213 | TUBULYSIN D | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1643767 | — | IC50 | = | 6300.0 | nM | 5.20 |