Assay Detail
Functional
CHEMBL1645643
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Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.49 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.00 |
| CHEMBL1643765 | 11-EPI-TUBULYSIN D | — | 1 | 8.51 |
| CHEMBL1643766 | 13-EPI-TUBULYSIN D | — | 1 | 7.01 |
| CHEMBL1643767 | — | — | 1 | 5.44 |
| CHEMBL455213 | TUBULYSIN D | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1643765 | 11-EPI-TUBULYSIN D | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1643766 | 13-EPI-TUBULYSIN D | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL1643767 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL455213 | TUBULYSIN D | IC50 | = | 0.0047 | nM | - |