Assay Detail
Binding
CHEMBL1645697
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Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay
56
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Stylophora pistillata |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alpha carbonic anhydrase (CHEMBL1075028) ↗| Type | SINGLE PROTEIN |
| Organism | Stylophora pistillata |
Publication
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 56 | 7.09 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355001 | SULFAMIDE | — | 1 | 11.00 |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | 9.17 |
| CHEMBL364571 | PHENYLARSONIC ACID | — | 1 | 9.11 |
| CHEMBL68253 | SULFAMATE | — | 1 | 9.09 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.80 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.74 |
| CHEMBL7146 | — | — | 1 | 7.71 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 7.69 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.67 |
| CHEMBL6633 | — | — | 1 | 7.59 |
| CHEMBL268439 | — | — | 1 | 7.56 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.54 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 7.54 |
| CHEMBL266026 | — | — | 1 | 7.53 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.47 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.41 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 7.39 |
| CHEMBL328560 | SULTHIAME | 3.0 | 1 | 7.34 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.32 |
| CHEMBL6853 | — | — | 1 | 7.12 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 7.08 |
| CHEMBL7092 | — | — | 1 | 7.06 |
| CHEMBL268177 | — | — | 1 | 7.05 |
| CHEMBL6753 | — | — | 1 | 7.04 |
| CHEMBL7087 | — | — | 1 | 7.03 |
| CHEMBL6724 | — | — | 1 | 6.98 |
| CHEMBL265674 | — | — | 1 | 6.98 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.79 |
| CHEMBL451332 | — | — | 1 | 6.59 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355001 | SULFAMIDE | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL21485 | PHENYLBORONIC ACID | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL364571 | PHENYLARSONIC ACID | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL68253 | SULFAMATE | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 18.1 | nM | 7.74 |
| CHEMBL7146 | — | Ki | = | 19.7 | nM | 7.71 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 20.4 | nM | 7.69 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 21.2 | nM | 7.67 |
| CHEMBL6633 | — | Ki | = | 25.4 | nM | 7.59 |
| CHEMBL268439 | — | Ki | = | 27.6 | nM | 7.56 |
| CHEMBL865 | VALDECOXIB | Ki | = | 28.7 | nM | 7.54 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 29.1 | nM | 7.54 |
| CHEMBL266026 | — | Ki | = | 29.8 | nM | 7.53 |
| CHEMBL118 | CELECOXIB | Ki | = | 34.2 | nM | 7.47 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 39.4 | nM | 7.41 |
| CHEMBL310671 | SACCHARIN | Ki | = | 40.3 | nM | 7.39 |
| CHEMBL328560 | SULTHIAME | Ki | = | 45.2 | nM | 7.34 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 48.2 | nM | 7.32 |
| CHEMBL6853 | — | Ki | = | 75.1 | nM | 7.12 |
| CHEMBL419 | MAFENIDE | Ki | = | 82.5 | nM | 7.08 |
| CHEMBL7092 | — | Ki | = | 87.5 | nM | 7.06 |
| CHEMBL268177 | — | Ki | = | 88.3 | nM | 7.05 |
| CHEMBL6753 | — | Ki | = | 91.9 | nM | 7.04 |
| CHEMBL7087 | — | Ki | = | 94.3 | nM | 7.03 |
| CHEMBL6724 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL265674 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL77517 | INDISULAM | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL451332 | — | Ki | = | 256.0 | nM | 6.59 |
| CHEMBL266240 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 364.0 | nM | 6.44 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 367.0 | nM | 6.43 |
| CHEMBL26 | SULPIRIDE | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 431.0 | nM | 6.37 |
| CHEMBL414 | CARZENIDE | Ki | = | 435.0 | nM | 6.36 |
| CHEMBL6705 | — | Ki | = | 553.0 | nM | 6.26 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 614.0 | nM | 6.21 |
| CHEMBL6919 | — | Ki | = | 768.0 | nM | 6.12 |
| CHEMBL6784 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL176495 | — | Ki | = | 2510.0 | nM | 5.60 |
| CHEMBL1233550 | IODIDE | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL1231461 | BROMIDE | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL1161632 | BICARBONATE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1231821 | HYDROCHLORIC ACID | Ki | = | 500000.0 | nM | - |
| CHEMBL1362 | FLUORIDE ION | Ki | = | 620000.0 | nM | - |
| CHEMBL1161700 | CYANATE | Ki | = | 590000.0 | nM | - |
| CHEMBL84336 | THIOCYANIC ACID | Ki | = | 680000.0 | nM | - |
| CHEMBL183419 | CYANIDE | Ki | = | 580000.0 | nM | - |
| CHEMBL186537 | — | Ki | = | 520000.0 | nM | - |