Assay Detail
Functional
CHEMBL1645699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against EGFR-deficient human PC9 cells
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of selective irreversible inhibitors for EGFR-T790M.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 39 | 6.45 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643989 | — | — | 1 | 8.22 |
| CHEMBL1643976 | — | — | 1 | 7.82 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.77 |
| CHEMBL1643988 | — | — | 1 | 7.70 |
| CHEMBL1229592 | — | — | 1 | 7.44 |
| CHEMBL1643990 | — | — | 1 | 7.40 |
| CHEMBL1643994 | — | — | 1 | 7.10 |
| CHEMBL1643977 | — | — | 1 | 7.10 |
| CHEMBL1643973 | — | — | 1 | 7.00 |
| CHEMBL1643974 | — | — | 1 | 7.00 |
| CHEMBL1643972 | — | — | 1 | 6.70 |
| CHEMBL1643963 | — | — | 1 | 6.52 |
| CHEMBL1643964 | — | — | 1 | 6.30 |
| CHEMBL1643982 | — | — | 1 | 6.30 |
| CHEMBL1643995 | — | — | 1 | 6.16 |
| CHEMBL1643981 | — | — | 1 | 6.10 |
| CHEMBL1643996 | — | — | 1 | 6.10 |
| CHEMBL1643978 | — | — | 1 | 6.10 |
| CHEMBL1643962 | — | — | 1 | 6.05 |
| CHEMBL1643960 | — | — | 1 | 6.00 |
| CHEMBL1643967 | — | — | 1 | 5.22 |
| CHEMBL1643965 | — | — | 1 | 5.22 |
| CHEMBL1643966 | — | — | 1 | 5.22 |
| CHEMBL1643959 | — | — | 1 | 5.16 |
| CHEMBL1643961 | — | — | 1 | 5.00 |
| CHEMBL1643968 | — | — | 1 | 5.00 |
| CHEMBL1643986 | — | — | 1 | - |
| CHEMBL1643993 | — | — | 1 | - |
| CHEMBL1643992 | — | — | 1 | - |
| CHEMBL1643991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643989 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1643976 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL939 | GEFITINIB | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1643988 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1229592 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1643990 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1643994 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1643977 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1643973 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1643974 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1643972 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1643963 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1643964 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1643982 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1643995 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1643981 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1643978 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1643996 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1643962 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1643960 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1643965 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1643966 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1643967 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1643959 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1643961 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1643968 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1643971 | — | EC50 | - | — | - | |
| CHEMBL1643970 | — | EC50 | - | — | - | |
| CHEMBL1643969 | — | EC50 | - | — | - | |
| CHEMBL1643979 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1643983 | — | EC50 | - | — | - | |
| CHEMBL1643984 | — | EC50 | - | — | - | |
| CHEMBL1643985 | — | EC50 | - | — | - | |
| CHEMBL1643975 | — | EC50 | - | — | - | |
| CHEMBL1643987 | — | EC50 | - | — | - | |
| CHEMBL1643991 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1643992 | — | EC50 | - | — | - | |
| CHEMBL1643993 | — | EC50 | - | — | - | |
| CHEMBL1643986 | — | EC50 | - | — | - |